2. Signaling Pathways
  3. Apoptosis
  4. Bcl-2 Family
  5. Bak Isoform
  6. Bak Inhibitor

Bak Inhibitor

Bak Inhibitors (3):

Cat. No. Product Name Effect Purity
  • HY-120079
    MSN-125
    		Inhibitor 99.00%
    MSN-125 is a potent Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilization (MOMP) with an IC50 of 4 μM. MSN-125 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity.
  • HY-118948
    MSN-50
    		Inhibitor 98.40%
    MSN-50 is a Bax and Bak oligomerization inhibitor. MSN-50 efficiently inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection.
  • HY-100383
    BH3I-1
    		Inhibitor ≥98.0%
    BH3I-1 is a Bcl-2 family antagonist, which inhibits the binding of the Bak BH3 peptide to Bcl-xL with a Ki of 2.4±0.2 μM in FP assay. BH3I-1 has a Kd of 5.3 μM against the p53/MDM2 pair.